Deficiency in the membrane protein Tmbim3a/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish

Most members of the family of proteins containing a transmembrane BAX inhibitor motif (TMBIM) have anti-apoptotic activity, but their in vivo functions and intracellular mechanisms remain obscure. Here, we report that zebrafish Tmbim3a/Grinaa functions in the prevention of cold-induced endoplasmic r...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Chen, Kai, Li, Xixi, Song, Guili, Zhou, Tong, Long, Yong, Li, Qing, Zhong, Shan, Cui, Zongbin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663883/
https://ncbi.nlm.nih.gov/pubmed/31171717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007813
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