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Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs)

Human telomerase maintains genome stability by adding telomeric repeats to the ends of linear chromosomes. Although previous studies have revealed profound insights into telomerase functions, the low cellular abundance of functional telomerase and the difficulties in quantifying its activity leave i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sayed, Mohammed E., Cheng, Ao, Yadav, Gaya P., Ludlow, Andrew T., Shay, Jerry W., Wright, Woodring E., Jiang, Qiu-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663873/
https://ncbi.nlm.nih.gov/pubmed/31186347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007234
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