Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival

Neurofibromatosis type 2 (NF2) is an autosomal-dominant disorder characterized by the development of bilateral vestibular schwannomas. The NF2 gene encodes the tumor suppressor merlin, and loss of merlin activity promotes tumorigenesis and causes NF2. Cellular redox signaling has been implicated in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Pestoni, Jeanine C., Klingeman Plati, Stephani, Valdivia Camacho, Oliver D., Fuse, Marisa A., Onatunde, Maria, Sparrow, Nicklaus A., Karajannis, Matthias A., Fernández-Valle, Cristina, Franco, Maria Clara
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2019
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663865/
https://ncbi.nlm.nih.gov/pubmed/31171721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007152
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