Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival

Neurofibromatosis type 2 (NF2) is an autosomal-dominant disorder characterized by the development of bilateral vestibular schwannomas. The NF2 gene encodes the tumor suppressor merlin, and loss of merlin activity promotes tumorigenesis and causes NF2. Cellular redox signaling has been implicated in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pestoni, Jeanine C., Klingeman Plati, Stephani, Valdivia Camacho, Oliver D., Fuse, Marisa A., Onatunde, Maria, Sparrow, Nicklaus A., Karajannis, Matthias A., Fernández-Valle, Cristina, Franco, Maria Clara
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663865/
https://ncbi.nlm.nih.gov/pubmed/31171721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007152
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