Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action

Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although the underlying mechanism(s) remain unknown. Using FRET-based nanosensors we found that ketamine increases [cAMP](i) in astrocytes. Membrane capacitance recordings, however, reveal fundamentally distinct mech...

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Pubblicato in:Sci Rep
Autori principali: Lasič, Eva, Lisjak, Marjeta, Horvat, Anemari, Božić, Mićo, Šakanović, Aleksandra, Anderluh, Gregor, Verkhratsky, Alexei, Vardjan, Nina, Jorgačevski, Jernej, Stenovec, Matjaž, Zorec, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662760/
https://ncbi.nlm.nih.gov/pubmed/31358895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47459-z
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