Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human

Human NAT1 gene for N-acetyltransferase 1 modulates xenobiotic metabolism of arylamine drugs and mutagens. Beyond pharmacogenetics, NAT1 is also relevant to breast cancer. The population history of human NAT1 suggests evolution through purifying selection, but it is unclear whether this pattern is e...

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Udgivet i:Sci Rep
Main Authors: Boukouvala, Sotiria, Chasapopoulou, Zoi, Giannouri, Despina, Kontomina, Evanthia, Marinakis, Nikolaos, Rizou, Sophia V., Stefani, Ioanna, Tsirka, Theodora, Veyssière, Charlotte, Zaliou, Sofia, Sabbagh, Audrey, Crouau-Roy, Brigitte, Fakis, Giannoulis
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662693/
https://ncbi.nlm.nih.gov/pubmed/31358821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47485-x
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