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Broad-spectrum protein kinase inhibition by the staurosporine analog KT-5720 reverses ethanol withdrawal-associated loss of NeuN/Fox-3

Chronic, intermittent ethanol (CIE) exposure is known to produce neuroadaptive alterations in excitatory neurotransmission that contribute to the development of dependence. Although activation of protein kinases (e.g., cyclic AMP [cAMP]-dependent protein kinase) is implicated in the synaptic traffic...

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Detalhes bibliográficos
Publicado no:Alcohol
Principais autores: Reynolds, Anna R., Saunders, Meredith A., Berry, Jennifer N., Sharrett-Field, Lynda J., Winchester, Sydney, Prendergast, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662204/
https://ncbi.nlm.nih.gov/pubmed/28965654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alcohol.2017.05.006
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