4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

BACKGROUND: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

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Detalles Bibliográficos
Publicado en:BMC Chem
Main Authors: Tahlan, Sumit, Ramasamy, Kalavathy, Lim, Siong Meng, Shah, Syed Adnan Ali, Mani, Vasudevan, Narasimhan, Balasubramanian
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6661798/
https://ncbi.nlm.nih.gov/pubmed/31384761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-019-0533-7
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