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Dominant PAX2 mutations may cause steroid resistant neprotic syndrome and FSGS in children

BACKGROUND: Heterozygous PAX2 mutations cause renal coloboma syndrome (RCS) [OMIM# # 120330]. RCS is a renal syndromic disease encompassing retinal coloboma and sensorineural hearing loss. Recently a causative role for PAX2 was reported in adult-onset nephrotic syndrome secondary to focal segmental...

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Publicat a:Pediatr Nephrol
Autors principals: Vivante, Asaf, Chacham, Orna, Shril, Shirlee, Schreiber, Ruth, Soliman, Neveen A., Koneth, Irene, Schiffer, Mario, Anikster, Yair, Hildebrandt, Friedhelm
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660980/
https://ncbi.nlm.nih.gov/pubmed/31001663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00467-019-04256-0
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