Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression

BACKGROUND: To clarify the effects of cylcin E1 expression on HCC tumor progression, we studied the expression of cyclin E1 and inhibitory efficacy of regorafenib and sorafenib in HCC cells, and investigated a potential therapy that combines regorafenib treatment with cyclin E1 inhibition. METHODS:...

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Publicat a:Cell Commun Signal
Autors principals: Xu, Jianliang, Huang, Fei, Yao, Zhicheng, Jia, Changchang, Xiong, Zhiyong, Liang, Hao, Lin, Nan, Deng, Meihai
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660968/
https://ncbi.nlm.nih.gov/pubmed/31349793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0398-3
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