Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation

The infrapatellar fat pad (IFP) serves as a reservoir of Mesenchymal Stem Cells (MSC), and with adjacent synovium plays key roles in joint disease including the production of Substance P (SP) affecting local inflammatory responses and transmitting nociceptive signals. Here, we interrogate human IFP-...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kouroupis, Dimitrios, Bowles, Annie C., Willman, Melissa A., Perucca Orfei, Carlotta, Colombini, Alessandra, Best, Thomas M., Kaplan, Lee D., Correa, Diego
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659713/
https://ncbi.nlm.nih.gov/pubmed/31350444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47391-2
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