Beta-2 Adrenergic and Glucocorticoid Receptor Agonists Modulate Ozone-Induced Pulmonary Protein Leakage and Inflammation in Healthy and Adrenalectomized Rats

We have shown that acute ozone inhalation activates sympathetic-adrenal-medullary and hypothalamus-pituitary-adrenal stress axes, and adrenalectomy (AD) inhibits ozone-induced lung injury and inflammation. Therefore, we hypothesized that stress hormone receptor agonists (β2 adrenergic-β(2)AR and glu...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Henriquez, Andres R, Snow, Samantha J, Schladweiler, Mette C, Miller, Colette N, Dye, Janice A, Ledbetter, Allen D, Richards, Judy E, Hargrove, Marie M, Williams, Wanda C, Kodavanti, Urmila P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Beta-2 Adrenergic Signaling and Ozone-Related Pulmonary Damage
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659033/
https://ncbi.nlm.nih.gov/pubmed/30379318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy198
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