Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy

OBJECTIVE: This phase I/II study sought to explore intrathecal administration of mesenchymal stem cells (MSCs) as therapeutic approach to multiple system atrophy (MSA). METHODS: Utilizing a dose-escalation design, we delivered between 10 and 200 million adipose-derived autologous MSCs intrathecally...

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Bibliografiska uppgifter
I publikationen:Neurology
Huvudupphovsmän: Singer, Wolfgang, Dietz, Allan B., Zeller, Anita D., Gehrking, Tonette L., Schmelzer, James D., Schmeichel, Ann M., Gehrking, Jade A., Suarez, Mariana D., Sletten, David M., Minota Pacheco, Karla V., Coon, Elizabeth A., Sandroni, Paola, Benarroch, Eduardo E., Fealey, Robert D., Matsumoto, Joseph Y., Bower, James H., Hassan, Anhar, McKeon, Andrew, Windebank, Anthony J., Mandrekar, Jay N., Low, Phillip A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Lippincott Williams & Wilkins 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659003/
https://ncbi.nlm.nih.gov/pubmed/31152011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000007720
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