Comparison of Different Liver Test Thresholds for Drug-Induced Liver Injury: Updated RUCAM versus Other Methods

According to the updated Roussel Uclaf Causality Assessment Method (RUCAM), drug-induced liver injury (DILI) is currently defined based on thresholds of alanine aminotransferase (ALT) levels above 5 × the upper limit of normal (ULN) and/or alkaline phosphatase (ALP) levels greater than 2 × the ULN....

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Publicado en:Front Pharmacol
Autores principales: Yang, Hongyi, Guo, Daihong, Xu, Yuanjie, Zhu, Man, Yao, Chong, Chen, Chao, Jia, Wangping
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658872/
https://ncbi.nlm.nih.gov/pubmed/31379581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00816
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