Nonnucleoside Reverse Transcriptase Inhibitor Hypersusceptibility and Resistance by Mutation of Residue 181 in HIV-1 Reverse Transcriptase

Substitutions at residue Y181 in HIV-1 reverse transcriptase (RT), in particular, Y181C, Y181I, and Y181V, are associated with nonnucleoside RT inhibitor (NNRTI) cross-resistance. In this study, we used kinetic and thermodynamic approaches, in addition to molecular modeling, to gain insight into the...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Barnard, John P., Huber, Kelly D., Sluis-Cremer, Nicolas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658764/
https://ncbi.nlm.nih.gov/pubmed/31160281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00676-19
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