Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection

The emergence of multidrug-resistant Klebsiella pneumoniae has rendered a large array of infections difficult to treat. In a high-throughput genetic screen of factors required for K. pneumoniae survival in the lung, amino acid biosynthesis genes were critical for infection in both immunosuppressed a...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Silver, Rebecca J., Paczosa, Michelle K., McCabe, Anne L., Balada-Llasat, Joan-Miquel, Baleja, James D., Mecsas, Joan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658747/
https://ncbi.nlm.nih.gov/pubmed/31109974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02674-18
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