Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Novopashina, Darya, Vorobyeva, Mariya, Nazarov, Anton, Davydova, Anna, Danilin, Nikolay, Koroleva, Lyudmila, Matveev, Andrey, Bardasheva, Alevtina, Tikunova, Nina, Kupryushkin, Maxim, Pyshnyi, Dmitrii, Altman, Sidney, Venyaminova, Alya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658616/
https://ncbi.nlm.nih.gov/pubmed/31379580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00813
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