Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Novopashina, Darya, Vorobyeva, Mariya, Nazarov, Anton, Davydova, Anna, Danilin, Nikolay, Koroleva, Lyudmila, Matveev, Andrey, Bardasheva, Alevtina, Tikunova, Nina, Kupryushkin, Maxim, Pyshnyi, Dmitrii, Altman, Sidney, Venyaminova, Alya
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658616/
https://ncbi.nlm.nih.gov/pubmed/31379580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00813
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