Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Novopashina, Darya, Vorobyeva, Mariya, Nazarov, Anton, Davydova, Anna, Danilin, Nikolay, Koroleva, Lyudmila, Matveev, Andrey, Bardasheva, Alevtina, Tikunova, Nina, Kupryushkin, Maxim, Pyshnyi, Dmitrii, Altman, Sidney, Venyaminova, Alya
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658616/
https://ncbi.nlm.nih.gov/pubmed/31379580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00813
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