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Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P
Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...
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| Izdano u: | Front Pharmacol |
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| Glavni autori: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6658616/ https://ncbi.nlm.nih.gov/pubmed/31379580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00813 |
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