Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Novopashina, Darya, Vorobyeva, Mariya, Nazarov, Anton, Davydova, Anna, Danilin, Nikolay, Koroleva, Lyudmila, Matveev, Andrey, Bardasheva, Alevtina, Tikunova, Nina, Kupryushkin, Maxim, Pyshnyi, Dmitrii, Altman, Sidney, Venyaminova, Alya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658616/
https://ncbi.nlm.nih.gov/pubmed/31379580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00813
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