Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Cerebral blood flow is reduced early in Alzheimer’s disease (AD). Because most of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of contractile pericytes on capillary walls. Here we used live and rapidly-fixed biopsied human tissue to establish disease-rel...

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發表在:Science
Main Authors: Nortley, Ross, Korte, Nils, Izquierdo, Pablo, Hirunpattarasilp, Chanawee, Mishra, Anusha, Jaunmuktane, Zane, Kyrargyri, Vasiliki, Pfeiffer, Thomas, Khennouf, Lila, Madry, Christian, Gong, Hui, Richard-Loendt, Angela, Huang, Wenhui, Saito, Takashi, Saido, Takaomi C., Brandner, Sebastian, Sethi, Huma, Attwell, David
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658218/
https://ncbi.nlm.nih.gov/pubmed/31221773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9518.
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