Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Cerebral blood flow is reduced early in Alzheimer’s disease (AD). Because most of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of contractile pericytes on capillary walls. Here we used live and rapidly-fixed biopsied human tissue to establish disease-rel...

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Publicado no:Science
Main Authors: Nortley, Ross, Korte, Nils, Izquierdo, Pablo, Hirunpattarasilp, Chanawee, Mishra, Anusha, Jaunmuktane, Zane, Kyrargyri, Vasiliki, Pfeiffer, Thomas, Khennouf, Lila, Madry, Christian, Gong, Hui, Richard-Loendt, Angela, Huang, Wenhui, Saito, Takashi, Saido, Takaomi C., Brandner, Sebastian, Sethi, Huma, Attwell, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658218/
https://ncbi.nlm.nih.gov/pubmed/31221773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9518.
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