Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease?

Copper/zinc superoxide dismutase 1 (SOD1) scavenges free radicals that may otherwise damage brain parenchyma. Impaired SOD1 activity drives Alzheimer's disease (AD) neuropathology in animal models and postmortem AD brains. Yet, it is unknown how cerebrospinal fluid (CSF) SOD1 is related in vivo...

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Bibliographic Details
Published in:Antioxid Redox Signal
Main Authors: McLimans, Kelsey E., Clark, Bridget E., Plagman, Alexandra, Pappas, Colleen, Klinedinst, Brandon, Anatharam, Vellareddy, Kanthasamy, Anumantha, Willette, Auriel A.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc., publishers 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657291/
https://ncbi.nlm.nih.gov/pubmed/31088292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7762
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