Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease?

Copper/zinc superoxide dismutase 1 (SOD1) scavenges free radicals that may otherwise damage brain parenchyma. Impaired SOD1 activity drives Alzheimer's disease (AD) neuropathology in animal models and postmortem AD brains. Yet, it is unknown how cerebrospinal fluid (CSF) SOD1 is related in vivo...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Principais autores: McLimans, Kelsey E., Clark, Bridget E., Plagman, Alexandra, Pappas, Colleen, Klinedinst, Brandon, Anatharam, Vellareddy, Kanthasamy, Anumantha, Willette, Auriel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
News & Views
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657291/
https://ncbi.nlm.nih.gov/pubmed/31088292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7762
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