Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

BACKGROUND: Doxorubicin (DOX) is one of the most important anticancer agents used in treating breast cancer. However, chronic cardiotoxicity and multidrug resistance limit the chemotherapeutic use of DOX. METHODS: This study aimed to evaluate the capability of calcium channel blocker diltiazem (DIL)...

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Foilsithe in:Cancer Cell Int
Main Authors: Al-malky, Hamdan S., Osman, Abdel-Moneim M., Damanhouri, Zoheir A., Alkreathy, Huda M., Al Aama, Jumana Y., Ramadan, Wafaa S., Al Qahtani, Ali A., Al Mahdi, Hadiah B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2019
Ábhair:
Primary Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657176/
https://ncbi.nlm.nih.gov/pubmed/31367189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0912-0
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