Concentration–QT Modeling Following Inhalation of the Novel Inhaled Phosphodiesterase‐4 Inhibitor CHF6001 in Healthy Volunteers Shows an Absence of QT Prolongation

Concentration‐QTcF data obtained from two phase I studies in healthy volunteers treated with a novel phosphodiesterase‐4 inhibitor currently under development for the treatment of chronic obstructive pulmonary disease were analyzed by means of mixed‐effects modeling. A simple linear mixed‐effects mo...

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Vydáno v:CPT Pharmacometrics Syst Pharmacol
Hlavní autoři: Jolling, Koen, Äbelö, Angela, Luyckx, Nicolas, Nandeuil, Marie‐Anna, Govoni, Mirco, Cella, Massimo, Lindauer, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656937/
https://ncbi.nlm.nih.gov/pubmed/31077576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12405
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