Organoid modeling of the tumor immune microenvironment

In vitro cancer cultures, including 3-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes...

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Udgivet i:Cell
Main Authors: Neal, James T., Li, Xingnan, Zhu, Junjie, Giangarra, Valeria, Grzeskowiak, Caitlin L., Ju, Jihang, Liu, Iris H., Chiou, Shin-Heng, Salahudeen, Ameen A., Smith, Amber R., Deutsch, Brian C., Liao, Lillian, Zemek, Allison J., Zhao, Fan, Karlsson, Kasper, Schultz, Liora M., Metzner, Thomas J., Nadauld, Lincoln D., Tseng, Yuen-Yi, Alkhairy, Sahar, Oh, Coyin, Keskula, Paula, Mendoza-Villanueva, Daniel, De La Vega, Francisco M., Kunz, Pamela L., Liao, Joseph C., Leppert, John T., Sunwoo, John B., Sabatti, Chiara, Boehm, Jesse S., Hahn, William C., Zheng, Grace X.Y., Davis, Mark M., Kuo, Calvin J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656687/
https://ncbi.nlm.nih.gov/pubmed/30550791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.021
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