Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes

Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. Here, we analyzed the RNA expression patterns of more than 76,000 individual microglia in mice during develo...

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Publicado en:Immunity
Autores principales: Hammond, Timothy R., Dufort, Connor, Dissing-Olesen, Lasse, Giera, Stefanie, Young, Adam, Wysoker, Alec, Walker, Alec J., Gergits, Frederick, Segel, Michael, Nemesh, James, Marsh, Samuel E., Saunders, Arpiar, Macosko, Evan, Ginhoux, Florent, Chen, Jinmiao, Franklin, Robin J. M., Piao, Xianhua, McCarroll, Steven A., Stevens, Beth
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6655561/
https://ncbi.nlm.nih.gov/pubmed/30471926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.11.004
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