A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas

PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the majority subunit of the type IV pilus (PilA), two major antigens of nontypeable Haemophilus influenzae (NTHi). Here we report on the preclinical evaluation of PE-PilA as a vaccine antigen. The immunogeni...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Ysebaert, Carine, Denoël, Philippe, Weynants, Vincent, Bakaletz, Lauren O., Novotny, Laura A., Godfroid, Fabrice, Hermand, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652774/
https://ncbi.nlm.nih.gov/pubmed/31109946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00345-19
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