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Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation

Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atr...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Chan, Chao-Shun, Lin, Yung-Kuo, Chen, Yao-Chang, Lu, Yen-Yu, Chen, Shih-Ann, Chen, Yi-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651382/
https://ncbi.nlm.nih.gov/pubmed/31262061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133224
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