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Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation

Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atr...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Chan, Chao-Shun, Lin, Yung-Kuo, Chen, Yao-Chang, Lu, Yen-Yu, Chen, Shih-Ann, Chen, Yi-Jen
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651382/
https://ncbi.nlm.nih.gov/pubmed/31262061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133224
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