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A Designed Heme-[4Fe-4S] Metalloenzyme Catalyzes Sulfite Reduction Like the Native Enzyme

Multi-electron redox reactions often require multi-cofactor metalloenzymes to facilitate coupled electron and proton movement, but it is challenging to design artificial enzymes to catalyze these important reactions due to their structural and functional complexity. We report a designed heteronuclea...

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Bibliografiske detaljer
Udgivet i:Science
Main Authors: Mirts, Evan N., Petrik, Igor D., Hosseinzadeh, Parisa, Nilges, Mark J., Lu, Yi
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650743/
https://ncbi.nlm.nih.gov/pubmed/30213908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat8474
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