HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules

The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment was performed with baseline and longitudinal PBMC samples of a cohort of patients...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Ackermann, Christin, Smits, Maike, Woost, Robin, Eberhard, Johanna M., Peine, Sven, Kummer, Silke, Marget, Matthias, Kuntzen, Thomas, Kwok, William W., Lohse, Ansgar W., Jacobs, Thomas, Boettler, Tobias, Schulze zur Wiesch, Julian
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650447/
https://ncbi.nlm.nih.gov/pubmed/31337800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47024-8
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