The Alzheimer’s disease-associated protein BACE1 modulates T cell activation and Th17 function

Beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is best known for its role in Alzheimer’s disease amyloid plaque formation, but also contributes to neurodegenerative processes triggered by CNS injury. Here we report that BACE1 is expressed in murine CD4(+) T cells and regulates signali...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Mir, Gerard Hernandez, Raphael, Itay, Revu, Shankar, Poholek, Catherine H, Avery, Lyndsay, Hawse, William F, Kane, Lawrence P, McGeachy, Mandy J
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650361/
https://ncbi.nlm.nih.gov/pubmed/31209103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800363
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