Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing

BACKGROUND: Genetic testing of cancer samples primarily focuses on protein-coding regions, despite most mutations arising in noncoding DNA. Noncoding mutations can be pathogenic if they disrupt gene regulation, but the benefits of assessing promoter mutations in driver genes by panel testing has not...

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Veröffentlicht in:JNCI Cancer Spectr
Hauptverfasser: Poulos, Rebecca C, Perera, Dilmi, Packham, Deborah, Shah, Anushi, Janitz, Caroline, Pimanda, John E, Hawkins, Nicholas, Ward, Robyn L, Hesson, Luke B, Wong, Jason W H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649856/
https://ncbi.nlm.nih.gov/pubmed/31360895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkz012
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