Germline Pathogenic Variants in Homologous Recombination and DNA Repair Genes in an Asian Cohort of Young-Onset Colorectal Cancer

BACKGROUND: Growing evidence suggests a role for cancer susceptibility genes such as BRCA2 and PALB2 in young-onset colorectal cancers. Using a cohort of young colorectal cancer patients, we sought to identify and provide functional evidence for germline pathogenic variants of DNA repair genes not t...

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Bibliografski detalji
Izdano u:JNCI Cancer Spectr
Glavni autori: Toh, Ming Ren, Chiang, Jian Bang, Chong, Siao Ting, Chan, Sock Hoai, Ishak, Nur Diana Binte, Courtney, Eliza, Lee, Wei Hao, Syed Abdillah Al, Syed Muhammad Fahmy Bin, Carson Allen, John, Lim, Kiat Hon, Davila, Sonia, Tan, Patrick, Lim, Weng Khong, Tan, Iain Bee Huat, Ngeow, Joanne
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649855/
https://ncbi.nlm.nih.gov/pubmed/31360874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pky054
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