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4,6-Dihydroxysalicylic Acid-Catalyzed Oxidative Condensation of Benzylic Amines and Aromatic Ketones for the Preparation of 2,4,6-Trisubstituted Pyridines and Its Application to Metal-Free Synthesis of G-Quadruplex Binding Ligands

[Image: see text] 4,6-Dihydroxysalicylic acid was activated under air to catalyze the one-pot oxidative condensation reaction of benzylamines with acetophenones in the presence of BF(3)·Et(2)O, affording 2,4,6-trisubstituted pyridines in yields of 59–91%. During this metal-free oxidative condensatio...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:ACS Omega
Κύριοι συγγραφείς: Dong, Chun-ping, Kodama, Shintaro, Nomoto, Akihiro, Ueshima, Michio, Ogawa, Akiya
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2019
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648211/
https://ncbi.nlm.nih.gov/pubmed/31459991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b00999
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