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Prospect and challenge of detecting dynamic gene copy number increases in stem cells by whole genome sequencing

ABSTRACT: Gene amplification is an evolutionarily well-conserved and highly efficient mechanism to increase the amount of specific proteins. In humans, gene amplification is a hallmark of cancer and has recently been found during stem cell differentiation. Amplifications in stem cells are restricted...

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Detalhes bibliográficos
Publicado no:J Mol Med (Berl)
Main Authors: Fischer, Ulrike, Backes, Christina, Fehlmann, Tobias, Galata, Valentina, Keller, Andreas, Meese, Eckart
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647207/
https://ncbi.nlm.nih.gov/pubmed/31134286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-019-01792-y
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