Comparison of Clinical Trial Changes in Primary Outcome and Reported Intervention Effect Size Between Trial Registration and Publication

IMPORTANCE: Primary outcome change could threaten the validity of a clinical trial; however, evidence about the consequences on the reported intervention effect size is unclear. OBJECTIVES: To examine the status of randomized clinical trials whose primary outcome changed between trial registration a...

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Detalhes bibliográficos
Publicado no:JAMA Netw Open
Main Authors: Chen, Tao, Li, Chao, Qin, Rui, Wang, Yang, Yu, Dahai, Dodd, James, Wang, Duolao, Cornelius, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646984/
https://ncbi.nlm.nih.gov/pubmed/31322690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.7242
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