Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling

RATIONALE: Alcohol use disorder (AUD) involves dysregulation of innate immune signaling in brain. Toll-like receptor 3 (TLR3), an innate immune receptor that is upregulated in post-mortem human alcoholics, leads to induction of interferon (IFN) signaling. IFNs have been linked to depressive-like sym...

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Bibliografiske detaljer
Udgivet i:Psychopharmacology (Berl)
Main Authors: Lawrimore, Colleen J., Coleman, Leon G., Crews, Fulton T.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2019
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646093/
https://ncbi.nlm.nih.gov/pubmed/30610351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-5153-8
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