Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

An aged circulatory environment can activate microglia, reduce neural precursor cell activity, and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe BECs in the aged mouse hippocampus express an inflammatory transcription...

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Published in:Nat Med
Main Authors: Yousef, Hanadie, Czupalla, Cathrin J., Lee, Davis, Chen, Michelle B., Burke, Ashley N., Zera, Kristy A., Zandstra, Judith, Berber, Elisabeth, Lehallier, Benoit, Mathur, Vidhu, Nair, Ramesh V., Bonanno, Liana N., Yang, Andrew C., Peterson, Todd, Hadeiba, Husein, Merkel, Taylor, Körbelin, Jakob, Schwaninger, Markus, Buckwalter, Marion S., Quake, Stephen R., Butcher, Eugene C., Wyss-Coray, Tony
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642642/
https://ncbi.nlm.nih.gov/pubmed/31086348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0440-4
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