Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci

Global growth in antibiotic resistance is a major social problem. A high level of resistance to fluoroquinolones requires the concurrent presence of at least 3 mutations in the target proteins—2 in DNA gyrase (GyrA) and 1 in topoisomerase IV (ParC), which occur in a stepwise manner. In the Escherich...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Tchesnokova, Veronika, Radey, Matthew, Chattopadhyay, Sujay, Larson, Lydia, Weaver, Jamie Lee, Kisiela, Dagmara, Sokurenko, Evgeni V.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642405/
https://ncbi.nlm.nih.gov/pubmed/31262826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903002116
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