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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases
Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of power, and joint tagging of two or more distinct causal variants by a single non-causal SNP, lead to inaccuracies in fine-mapping, with stochas...
Uloženo v:
| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642100/ https://ncbi.nlm.nih.gov/pubmed/31324808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11271-0 |
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