Structural Insights from Molecular Dynamics Simulations of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase

[Image: see text] Many natural organic compounds with pharmaceutical applications, including antibiotics (chlortetracycline and vancomycin), antifungal compounds (pyrrolnitrin), and chemotherapeutics (salinosporamide A and rebeccamycin) are chlorinated. Halogenating enzymes like tryptophan 7-halogen...

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Udgivet i:ACS Omega
Main Authors: Ainsley, Jon, Mulholland, Adrian J., Black, Gary W., Sparagano, Olivier, Christov, Christo Z., Karabencheva-Christova, Tatyana G.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6641897/
https://ncbi.nlm.nih.gov/pubmed/31458701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00385
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