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Holistic Prediction of Enantioselectivity in Asymmetric Catalysis

When faced with unfamiliar reaction space, synthetic chemists typically apply reported conditions (reagents, catalyst, solvent, additives) from closely-related reactions to new substrate types. Unfortunately, this approach often fails due to subtle, albeit important, differences in reaction requirem...

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Detalles Bibliográficos
Publicado en:Nature
Main Authors: Reid, Jolene P., Sigman, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6641578/
https://ncbi.nlm.nih.gov/pubmed/31316193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1384-z
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