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Synthesis of Asthma Drug Zafirlukast (Accolate) Using Intramolecular Oxidative Coupling via sp(3) C–H Bond Activation
[Image: see text] The FDA-approved drug for the treatment of asthma, zafirlukast, is synthesized engaging multiple catalytic reactions including a new method for the construction of 3-aroylindoles via oxidative cyclization. The highlights include transition-metal and peroxide free C–H bond activatio...
שמור ב:
| הוצא לאור ב: | ACS Omega |
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| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical Society
2018
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6641481/ https://ncbi.nlm.nih.gov/pubmed/31458657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00476 |
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