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Fe(II)/Fe(III) Redox Process Can Significantly Modulate the Conformational Dynamics and Electrostatics of Pirin in NF-κB Regulation
[Image: see text] Pirin is an iron (Fe)-dependent regulatory protein of nuclear factor κB (NF-κB) transcription factors. Binding studies have suggested that the oxidative state of iron plays a crucial role in modulating the binding of Pirin to NF-κB p65, in turn enhancing the binding of p65 to DNA....
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| Veröffentlicht in: | ACS Omega |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2016
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640773/ https://ncbi.nlm.nih.gov/pubmed/31457166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00231 |
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