An observer blinded, randomized, placebo-controlled, phase I dose escalation trial to evaluate the safety and immunogenicity of an inactivated West Nile virus Vaccine, HydroVax-001, in healthy adults

BACKGROUND: West Nile virus (WNV) is the most common mosquito-borne infection in the United States. HydroVax-001 WNV is a hydrogen peroxide inactivated, whole virion (WNV-Kunjin strain) vaccine adjuvanted with aluminum hydroxide. METHODS: We performed a phase 1, randomized, placebo-controlled, doubl...

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Vydáno v:Vaccine
Hlavní autoři: Woods, Christopher W., Sanchez, Ana M., Swamy, Geeta K., McClain, Micah T., Harrington, Lynn, Freeman, Debra, Poore, Elizabeth A., Slifka, Dawn K., Poer DeRaad, Danae E., Amanna, Ian J., Slifka, Mark K., Cai, Shu, Shahamatdar, Venus, Wierzbicki, Michael R., Amegashie, Cyrille, Walter, Emmanuel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640644/
https://ncbi.nlm.nih.gov/pubmed/30661836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.12.026
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