Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold

Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas...

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Udgivet i:Medchemcomm
Main Authors: Van de Bittner, Kyle C., Cameron, Rosannah C., Bustamante, Leyla Y., Bundela, Rudranuj, Kessans, Sarah A., Vorster, Jan, Nicholson, Matthew J., Parker, Emily J.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640557/
https://ncbi.nlm.nih.gov/pubmed/31391888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00143c
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