Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2'-O-Methyltransferase and the Endocytosis Signal of the Spike Protein

Porcine epidemic diarrhea virus (PEDV) causes high mortality in neonatal piglets; however, effective and safe vaccines are still not available. We hypothesized that inactivation of the 2′-O-methyltransferase (2′-O-MTase) activity of nsp16 and the endocytosis signal of the spike protein attenuates PE...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hou, Yixuan, Ke, Hanzhong, Kim, Jineui, Yoo, Dongwan, Su, Yunfang, Boley, Patricia, Chepngeno, Juliet, Vlasova, Anastasia N., Saif, Linda J., Wang, Qiuhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639265/
https://ncbi.nlm.nih.gov/pubmed/31118255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00406-19
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados