A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients

PURPOSE: Simvastatin has demonstrated anti-tumor activity in preclinical studies via tumor cell senescence, apoptosis, and anti-angiogenesis. This phase II trial evaluated the efficacy and toxicity profile of conventional XELOX and bevacizumab chemotherapy plus simvastatin in metastatic colorectal c...

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Veröffentlicht in:Cancer Res Treat
Hauptverfasser: Kim, Youjin, Kim, Tae Won, Han, Sae Won, Ahn, Joong Bae, Kim, Seung Tae, Lee, Jeeyun, Park, Joon Oh, Park, Young Suk, Lim, Ho Yeong, Kang, Won Ki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Cancer Association 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639242/
https://ncbi.nlm.nih.gov/pubmed/30477287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2018.379
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