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Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density
EPAC2 is a guanine nucleotide exchange factor that regulates GTPase activity of the small GTPase Rap and Ras and is highly enriched at synapses. Activation of EPAC2 has been shown to induce dendritic spine shrinkage and increase spine motility, effects that are necessary for synaptic plasticity. The...
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| Опубликовано в: : | Mol Cell Neurosci |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Academic Press
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6639166/ https://ncbi.nlm.nih.gov/pubmed/31059774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2019.05.001 |
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