Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K(+) Channels

[Image: see text] Gating of ion channels is based on structural transitions between open and closed states. To uncover the chemical basis of individual gates, we performed a comparative experimental and computational analysis between two K(+) channels, Kcv(S) and Kcv(NTS). These small viral encoded...

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Pubblicato in:J Am Chem Soc
Autori principali: Rauh, Oliver, Urban, Martin, Henkes, Leonhard M., Winterstein, Tobias, Greiner, Timo, Van Etten, James L., Moroni, Anna, Kast, Stefan M., Thiel, Gerhard, Schroeder, Indra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638992/
https://ncbi.nlm.nih.gov/pubmed/28499087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01158
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