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Evaluation of simulation models to mimic the distortions introduced into squiggles by nanopore sequencers and segmentation algorithms
Nucleotides ratcheted through the biomolecular pores of nanopore sequencers generate raw picoamperage currents, which are segmented into step-current level signals representing the nucleotide sequence. These ‘squiggles’ are a noisy, distorted representation of the underlying true stepped current lev...
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| Udgivet i: | PLoS One |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6638935/ https://ncbi.nlm.nih.gov/pubmed/31318901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219495 |
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