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Evaluation of simulation models to mimic the distortions introduced into squiggles by nanopore sequencers and segmentation algorithms

Nucleotides ratcheted through the biomolecular pores of nanopore sequencers generate raw picoamperage currents, which are segmented into step-current level signals representing the nucleotide sequence. These ‘squiggles’ are a noisy, distorted representation of the underlying true stepped current lev...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Smith, Michael, Chan, Rachel, Gordon, Paul
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638935/
https://ncbi.nlm.nih.gov/pubmed/31318901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219495
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