De novo design of self-assembling helical protein filaments

We describe a general computational approach to designing self-assembling helical filaments from monomeric proteins and use this approach to design proteins that assemble into micrometer-scale filaments with a wide range of geometries in vivo and in vitro. Cryo–electron microscopy structures of six...

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Udgivet i:Science
Main Authors: Shen, Hao, Fallas, Jorge A., Lynch, Eric, Sheffler, William, Parry, Bradley, Jannetty, Nicholas, Decarreau, Justin, Wagenbach, Michael, Vicente, Juan Jesus, Chen, Jiajun, Wang, Lei, Dowling, Quinton, Oberdorfer, Gustav, Stewart, Lance, Wordeman, Linda, Yoreo, James De, Jacobs-Wagner, Christine, Kollman, Justin, Baker, David
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637945/
https://ncbi.nlm.nih.gov/pubmed/30409885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau3775
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