An Initial Genetic Analysis of Gemcitabine-Induced High-Grade Neutropenia in Pancreatic Cancer Patients in CALGB 80303 (Alliance)

OBJECTIVES: One of the standard of care regimens for advanced pancreatic cancer is gemcitabine-based chemotherapy. The efficacy of gemcitabine is limited by dose-limiting hematologic toxicities especially neutropenia. Uncovering the variability of these toxicities attributed to germline DNA variatio...

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Опубликовано в: :Pharmacogenet Genomics
Главные авторы: Innocenti, Federico, Jiang, Chen, Sibley, Alexander B., Denning, Stefanie, Etheridge, Amy S., Watson, Dorothy, Niedzwiecki, Donna, Hatch, Ace J., Hurwitz, Herbert I., Nixon, Andrew B., Furukawa, Yoichi, Kubo, Michiaki, Crona, Daniel J., Kindler, Hedy L., McLeod, Howard L., Ratain, Mark J., Owzar, Kouros
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636684/
https://ncbi.nlm.nih.gov/pubmed/30889042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000375
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