An Initial Genetic Analysis of Gemcitabine-Induced High-Grade Neutropenia in Pancreatic Cancer Patients in CALGB 80303 (Alliance)

OBJECTIVES: One of the standard of care regimens for advanced pancreatic cancer is gemcitabine-based chemotherapy. The efficacy of gemcitabine is limited by dose-limiting hematologic toxicities especially neutropenia. Uncovering the variability of these toxicities attributed to germline DNA variatio...

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Detalhes bibliográficos
Publicado no:Pharmacogenet Genomics
Main Authors: Innocenti, Federico, Jiang, Chen, Sibley, Alexander B., Denning, Stefanie, Etheridge, Amy S., Watson, Dorothy, Niedzwiecki, Donna, Hatch, Ace J., Hurwitz, Herbert I., Nixon, Andrew B., Furukawa, Yoichi, Kubo, Michiaki, Crona, Daniel J., Kindler, Hedy L., McLeod, Howard L., Ratain, Mark J., Owzar, Kouros
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636684/
https://ncbi.nlm.nih.gov/pubmed/30889042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000375
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