The RNA-binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

PIWI-interacting RNAs (piRNAs) silence transposons in Drosophila ovaries, ensuring female fertility. Two coupled pathways generate germline piRNAs: the ping-pong cycle, in which the PIWI proteins Aubergine and Ago3 increase the abundance of pre-existing piRNAs, and the phased piRNA pathway, which ge...

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Udgivet i:Mol Cell
Main Authors: Ge, Daniel Tianfang, Wang, Wei, Tipping, Cindy, Gainetdinov, Ildar, Weng, Zhiping, Zamore, Phillip D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636356/
https://ncbi.nlm.nih.gov/pubmed/31076285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.04.006
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